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Symbol Name ID |
Cd86
CD86 antigen MGI:101773 |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Chronic lymphatic leukemia |
Autoimmunity |
Platelet antibody positive |
Cellular immunodeficiency |
Asthma |
| Disease(s) Associated with CD86 | |||||
| asthma | |||||
| autoimmune thrombocytopenic purpura | |||||
| chronic lymphocytic leukemia | |||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | abnormal T cell proliferation |
decreased T cell proliferation |
spleen hyperplasia |
abnormal B cell differentiation |
decreased B cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased regulatory T cell number |
increased T cell number |
absent spleen germinal center |
increased splenocyte number |
decreased IgG level |
abnormal CD4-positive, alpha-beta T cell physiology |
lymph node hyperplasia |
lymphoid hyperplasia |
abnormal humoral immune response |
increased interferon-gamma secretion |
decreased susceptibility to autoimmune diabetes |
increased susceptibility to autoimmune diabetes |
increased autoantibody level |
abnormal inflammatory response |
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| Availability | Mouse Genotype | ||||||||||||||||||||||
| Cd86tm1Shr/Cd86tm1Shr | |||||||||||||||||||||||
| Tg(H2-K-Cd86)7All/0 | ! | ||||||||||||||||||||||
| Tg(H2-K-Cd86)27All/0 | |||||||||||||||||||||||
| Tg(H2-K-Cd86)31All/0 | |||||||||||||||||||||||
| Tg(Igh-6-Cd86)1Akab/0 | |||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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